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ispH [2019-08-07 12:53:57]
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ispH [2019-08-07 12:53:57]

(E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase, 7th step in the MEP pathway of isoprenoid biosynthesis
Locus
BSU_25160
Isoelectric point
5.61
Molecular weight
34.77 kDa
Protein length
314 aa Sequence Blast
Gene length
945 bp Sequence Blast
Function
MEP pathway of isoprenoid biosynthesis
Product
(E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Essential
yes
E.C.
1.17.1.2
Synonyms
yqfP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of isoprenoids
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    2,596,535 2,597,479

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] --> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + 2 reduced [2Fe-2S]-[ferredoxin] (according to UniProt)

    • Protein family

  • ispH family (single member, according to UniProt)

    • Cofactors

  • Fe-S cluster PubMed

    • Structure

  • 3F7T (IspH from E. coli, 38% identity) PubMed

    • Expression and Regulation

    Operons

    Genes
    yqfQ-ispH
    Description
    PubMed
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    Genes
    ispH
    Description
    PubMed
    view in new tab

    References

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